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Anazodo, orcid.org/0000-0001-8864-035X This article was submitted to Alzheimers Disease and Related Dementias, a section of the journal Frontiers in Aging Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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DNA damage accumulation with age drives PARP hyperactivation, accelerating NAD+ depletion in a self-reinforcing cycle