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The relationship between peripheral and central OS markers is supported by evidence that glutathione and GSSG can cross the bloodbrain barrier through specific transporters [42]
Thus, replenishment of metabolic intermediates via the TCA cycle is vital to cancer cells, making them reliant on glutamine, a phenomenon called anaplerosis 8
"Survodutide Phase III SYNCHRONIZE-1 topline results." Press release, April 28, 2026
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