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Cisplatin in combination with AT-0174 extended survival in preclinical models ( Together, these studies highlighted the potential of metabolic reprogramming of the TME to overcome immunotherapy resistance and provide a basis for advancing dual IDO1/TDO2 inhibitors in clinical settings
10.1016/j.ejphar.2014.01.046 31 DuzelA.VlainicJ.AntunovicM.MalekinusicD.VrdoljakB.SamaraM.et al (2017)
Additionally, significant decreases in triglycerides and cholesterol were observed, highlighting Berberines beneficial impact on lipid metabolism
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