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They have shown to reduce the inflammatory response by decreasing the expression of proinflammatory cytokines and inhibiting matrix metalloproteinase activity and cell signaling pathways
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Clinical studies have demonstrated that GLP-1 receptor agonists can reduce various inflammatory biomarkers , including: C-reactive protein (CRP) : A general marker of systemic inflammation Interleukin-6 (IL-6) : A pro-inflammatory cytokine Tumour necrosis factor-alpha (TNF-) : Another key inflammatory mediator Plasminogen activator inhibitor-1 (PAI-1) : Associated with cardiovascular inflammation The magnitude of these effects varies between studies and may depend on baseline inflammatory status, degree of weight loss achieved, and individual patient characteristics
In the SURPASS studies, the reduction of the systolic blood pressure was primarily mediated through weight loss [40, 54, 55]
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