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they observed that the mean enzymatic activities of xenobiotic metabolizing enzymes such as cytochrome P450 1A1 (CYP1A1), aromatase (CYP19A1), and glutathione-S-transferase (GST) were lower in three placental microsomes and subcellular membrane fractions

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Wound repair gene activation TB-500 upregulates genes involved in extracellular matrix production and tissue remodeling

The iron overload triggered the transcriptional activation of IKK resulting in the transcription of NF-B, and TNF- and also activation of COXII and prostaglandins that stimulate inflammation and are responsible for pathophysiology [87,88]