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Methods Computer-aided molecular design, synthesis, and characterization All the computer-aided molecular design studies were performed in SZMAP/GamePlan 37 and vBrood 38 modules in OpenEye software and Molecular Operating Environment, MOE 39
The medication's primary mechanism relies on centrally acting appetite suppression and peripheral metabolic changes, not on nutrient absorption or protein metabolism
The CagriSema combination achieved over 20% weight loss in clinical trials - significantly more than either drug alone
