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For chitosan-DOX systems, such models would enable precision dosing: predicting that elderly patients with reduced cardiac function require dose adjustments not based solely on body surface area but on AI-forecasted cardiac versus tumor exposure ratios, potentially preventing cardiotoxicity while maintaining efficacy

Big Pharmas Role: Speculation about pharmaceutical companies influencing the FDAs decision highlights concerns about competition and access to new treatments

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Two symbols (**, ##, or $$) denote significant difference below 0.005, three symbols (***, ###, or $$$) denote significant below 0.0001