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Upon TGR5 activation, adenylyl cyclase (AC) converts ATP to cAMP, which subsequently activates protein kinase A (PKA) and cAMP response element-binding protein (CREB), participating in multiple cAMP signaling pathways (73)

In a 2012 Genome Medicine study, Campbell and colleagues identified 127 genes whose expression levels in lung tissue tracked with regional emphysema severity in smokers with chronic obstructive pulmonary disease, and used CMap to query 1,309 bioactive compounds against the reverse of that signature (Campbell et al., 2012)

However, it should be approached with care and only under expert guidance