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In STZ-treatment rats, Exendin-4 improved learning and memory performance, protected hippocampal neurons against degeneration, and reversed STZ-induced tau hyperphosphorylation through downregulation of GSK-3 activity (154, 155, 182)

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Initial studies of semaglutide were geared to the regulation of Type II diabetes sometimes called adult-onset diabetes that is closely linked to obesity

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Prescription trends reflect this shift: GLP-1 usage has skyrocketed, with overweight/obesity indications growing fastest

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