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A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study
The peptide has shown substantial therapeutic potential in experimental models of inflammatory bowel disease, gastric ulceration, and various gastrointestinal inflammatory conditions
Of note, over the last years, an array of unimolecular GLP1-based poly-agonists, with different mechanisms of action, have been developed and experimentally validated for the treatment of metabolic syndrome, holding superior efficacy relative to conventional GLP1-RA 33,34,35
103 Insulin resistance, even in the context of normal blood glucose levels, promotes unhealthy lipid metabolism and obesity, activates inflammatory pathways, and reduces NO production, promoting endothelial dysfunction and accelerated atherosclerosis
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