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Some fluorescent indicators react with cysteine, homocysteine, or other biological thiols in addition to glutathione
Repeated freeze-thaw cycles degrade the peptide
and people with conditions that cause nutrient malabsorption and/or gastrointestinal blood loss (such as celiac disease, ulcerative colitis, and Crohn's disease)
Given that NACA was able to counteract the effects of the ACOX1 gain-of-function mutation, antioxidant treatment was considered for patient#1 during a severe disease flare
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