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A very large fraction of published binding constants for melanocortin ligands, including those for cyclic analogues, peptidomimetics and candidate subtype-selective compounds, are reported as inhibition of I-NDP-alpha-MSH binding to membranes from cell lines stably expressing a single human receptor subtype

Researchers synthesized the four-amino acid sequence Ala-Glu-Asp-Gly to create a stable, reproducible research compound that could be studied without relying on biological extracts

Most peptide degradation is invisible

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