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A Phase 2 trial (NEJM, 2023) reported a mean body weight reduction of approximately 24.2% over 48 weeks at the highest dose in adults with obesity without type 2 diabetes
Once a prescription is approved, treatment can begin quickly
Clinical trial data shows that average weight loss increases with dose: participants on 2.4 mg semaglutide weekly lost approximately 15% of body weight over 68 weeks, compared to 10% at 1.7 mg and 6% at 1.0 mg
Both medications can cause similar side effects, including nausea, fatigue, and digestive discomfort during the adjustment phase
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