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Protocol restraint: Researchers can focus on timing and consistency instead of assuming that escalating the amount will always improve the signal
The mean change in body weight from baseline to week 104 was -15.2% in the semaglutide group (n = 152) versus -2.6% with placebo (n = 152), for an estimated treatment difference of -12.6 %-points (95% confidence interval, -15.3 to -9.8
Retatrutide is being investigated for its ability to reduce heart disease risk, particularly in patients with obesity and metabolic syndrome
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