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When P9 binds to ICAM-2, it triggers a signaling cascade that results in GLP-1 secretion
FGF19 subfamily members have weak affinity for heparan sulfate proteoglycans (HSPG) which allows them to escape from the extracellular compartment into circulation enabling them to function as endocrine hormones
We are not seeing an explosion of new research
Preclinical trials and clinical assessments of the drug have produced remarkable results, prompting the United States Food and Drug Administration (FDA) to approve its use as a first-in-class medicine in May 2022
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