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Because IGF-1 LR3 remains active longer than native IGF-1, it may provide extended stimulation of repair pathways, making it particularly valuable for individuals undergoing physical therapy or post-injury rehabilitation

& McKernan, L.C

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The expression of VE-cadherin (VE-Cad), an adherens junction protein and a key regulator of endothelial barrier function [77], was assessed in this model, showing cell elongation, which indicates the presence of a tight endothelial-like monolayer [43, 44]