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While some studies found no difference between individuals with T2DM and matched non-diabetic controls (6769), others found plasma DPP-4 activity to be reduced in the patients, and suggested this might reflect a compensatory response to the reduced insulin sensitivity and hyperglycaemia, in an attempt to increase intact incretin hormone concentrations and improve insulin secretion (70, 71)
10.2174/138161210790945977 117 SikiricP.SeiwerthS.GrabarevicZ.BalenI.AralicaG.GjurasinM.et al (2001)
& Fiedorowicz, J
Krner, M., Stckli, M., Waser, B
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