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Ethics approval The study was approved by the appropriate institutional and/or national research ethics committee, and was conducted in accordance with the ethical standards of the institutional and/or national research committee, the Declaration of Helsinki, and current guidelines for studies in patients with renal impairment

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Quantitative endpoints, such as MRI-PDFF and histology, can capture subtle yet clinically meaningful changes, whereas ALT/AST and ultrasonography may miss early metabolic improvements