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REDEFINE 1 (2025

doi: 10.3389/fphar.2026.1754721 Received 26 November 2025 Revised 28 February 2026 Accepted 03 March 2026 Published 19 March 2026 Volume 17 - 2026 Edited by Achuthan Raghavamenon, Amala Cancer Research Centre, India Reviewed by Abdul Rahim Chethikkattuveli Salih, Terasaki Institute for Biomedical Innovation, United States Julio Plaza-Diaz, Childrens Hospital of Eastern Ontario (CHEO), Canada Updates Copyright 2026 Hu, Tian, Yang, Zhang, Zhang, Xu and Lu

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While filler treatments restore volume and skin smoothness by adding material under the skin, Botox works instead by inactivating the facial muscles