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Locking the backbone into a ring reduces that conformational freedom, so a far larger proportion of molecules present the right shape at any moment, which raises apparent potency without changing the recognition sequence at all
This functional structure distinguishes this molecule from classical single receptor agonists and underpins its importance in studies of incretin signalling, glucose metabolism and energy balance
Before this past spring, many compounding pharmacies were selling copycat versions of GLP-1s, which the FDA permits if a drug is in shortage
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