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Adequate protein maximizes IGF-1 LR3 benefits
Failure to eliminate dysfunctional mitochondria leads to the accumulation of mitochondrial ROS and the release of immunogenic mtDNA, both of which act as DAMPs that activate innate immune pathways, including the NLRP3 inflammasome and type I interferon (IFN-I) signaling
Tirzepatide at 10 mg produces roughly 1,560 kcal per day of intervention with a similar plateau timeline
See Supplementary Table 2 for a list and working conditions of primary antibodies that we used in this study
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