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00:16:22 Vickie Danaher For now, wed also want to suggest oral semaglutide in patients who have cardiovascular disease, since semaglutide has the benefit of reducing the risk of MACE or major adverse cardiovascular events like CV death, heart attack, or stroke, but orforglipron doesnt yet have this indication
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TPNA10168 was found to inhibit dopaminergic neuronal death, and it was thought that heme oxygenase-1, an antioxidant enzyme expressed downstream of the Nrf2-ARE signalling pathway, might participate in this effect
