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Clinical evaluation should include comprehensive metabolic assessment with fasting glucose, hemoglobin A1C, lipid panel, and thyroid function tests
However, the magnitude of effect is considerably smaller than that achieved with pharmaceutical GLP-1 receptor agonists
IGF-1 LR3 is more potent than regular IGF-1 because of the decreased binding of Long R3 IGF-1 to IGF binding proteins, allowing it to remain active up to 120 times longer compared to native IGF-1
doi: 10.1038/ni.3023 93 SutherlandTERckerlDLoganNDuncanSWynnTAAllenJE
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