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[2] Normal doses are considered safe in pregnancy

Cecal levels of Erysipelatoclostridium abundance have been positively correlated with dyslipidemia 93 , and a report that WD decreased the relative abundance of Erysipelatoclostridium and that the abundance of Erysipelatoclostridium negatively correlated with obesity-related indices 90 may partially explain our observation that decreased levels of Erysipelatoclostridium were present in the 5A-1MQ-treated group and the WD control group relative to the vehicle-treated group switched from WD to LD

In subjects with renal impairment including end-stage renal disease (ESRD), no change in tirzepatide pharmacokinetics (PK) was observed [see Clinical Pharmacology (12.3)]

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