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More common with intramuscular administration than subcutaneous

Expectations should be adjusted accordingly, with longer protocol durations (8 to 12 weeks), potentially higher doses, and understanding that improvement may reach 70 to 90 percent of normal rather than complete resolution

Over multiple cycles, this contributes to: Physical aggregation (clumping) of peptide molecules Potential denaturation of three-dimensional structure Gradual loss of biological activity in research assays The practical solution is simple: aliquot before freezing

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