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Semaglutide Insomnia: Why You Feel "Wired" & How to Fix It Share Key Takeaways The Cause: GLP-1 medications may stimulate the Orexin ("alertness") pathway, creating a "wired" sensation
In a January interview, Tony Ren, head of Asia healthcare research at Macquarie Capital, said Chinese companies were likely to price their weight-loss drugs below Novo Nordisks semaglutide
Weight loss is a primary driver of downstream hormonal benefits, with semaglutide producing up to 15% body weight reduction over 68 weeks and a 2025 trial reporting a mean loss of 5.6 kg, compared with 2.3 kg with other treatments
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