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Orforglipron is the first small molecule GLP-1 to complete a Phase III trial, lowering A1C by an average of 1.3% to 1.6% across doses
It lists reduced appetite alongside nausea and mild fatigue among expected first-week effects
During the nine-month trial, none of the prediabetic subjects treated with curcumin progressed to diabetes, whereas over 16% of subjects in the control group were diagnosed with type 2 diabetes
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