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GLP-1R Antagonist 1 Based on 7 publication(s) in Google Scholar GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R) , with an IC 50 of 650 nM
The glucagon receptor activation at these doses enhances hepatic fat oxidation without the more pronounced GI effects of 12mg
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more than 90% of patients develop acute neuropathy which could become chronic in a 3050% of the cases
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