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The mechanistic plausibility is strong (NNMT inhibition increases NAD+ without the gastrointestinal side effects of high-dose nicotinamide), and the short-term tolerability profile is excellent, but we mean this sincerely: if you're using this compound for durations beyond what the published trials covered, you are operating in uncharted territory
While its quick and handy, this approach often yields a lower-tier PRP
During periods of extreme oxidative stress, the structural proteins and functional enzymes within our cells face the risk of irreversible oxidation, which can permanently destroy their function
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