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Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Without adequate decorin, collagen forms disorganized, weaker structures
Human lumbar vertebrae are required to withstand pressure from more than 50% of the body weight that is further influenced by our upright posture, whereas the spine of quadrupeds, of which most models are based on, does not bear such vertical pressure in the resting state
Two key enzymes that control histone modifications are histone methyltransferases and deacetylases, and dysregulation of these enzymes may play a role in HT pathogenesis (Pu And Zhang 2024)
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