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Because K+ channels are required for membrane repolarization in TASR, these cells remain in a depolarized state for an extended period, resulting in prolonged bitter signaling (74)
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Consistent with the effects of GCGR in increasing lipolysis and thermogenesis besides elevating blood glucose levels, preclinical studies have found that peptide 20 improved energy metabolism and hepatic lipid handling without exacerbating preexisting hyperglycemia 22
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