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Given that cAMP can act on different timescales modulating rapid neuronal excitability as well as longer-term cellular adaptations 2428 understanding the role of intracellular signaling mechanisms in regulating neuronal responses to semaglutide is crucial toward understanding the efficacy of GLP1-based drugs
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This may be due to lower food intake, dehydration, poor sleep, slower digestion, or simply drinking more than the body can comfortably tolerate while in a calorie deficit
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