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Also, it was shown that GSTP IleIle genotype interacts with blood manganese levels it was proven that this genotype increased the risk of ASD significantly, in children with high manganese blood levels 11

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Evidence established that a MERCS-specific E3 ubiquitin ligase, autocrine motility factor receptor (AMFR), ubiquitinates nascent proteins to activate TBK1 at the contact site (Watanabe et al., 2023)