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For patients with known asymptomatic gallstones who are about to start high-dose GLP-1 therapy, the balance is different and pre-emptive surgery may be reasonable
[5] Small-molecule NNMT inhibitors were then developed to reproduce that effect pharmacologically: in cultured adipocytes, 5-Amino-1MQ-type inhibitors lowered 1-methylnicotinamide, raised intracellular NAD and SAM, and suppressed lipogenesis
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