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An over-the-counter oral antihistamine like cetirizine (Zyrtec), loratadine (Claritin), or diphenhydramine (Benadryl) reduces histamine activity systemically and can relieve injection site itching within 30 to 60 minutes
The tardive dyskinesia risk is real and must be communicated
However, there are not many documented studies to confirm this effect
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