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NAD+: Universal coenzyme central to metabolism, DNA repair, and sirtuin activation
Kim KB, Kim YW, Lim SK, et al
Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RWF, Madl T, Hoeijmakers JHJ, Campisi J, de Keizer PLJ
In cells without oxidative stress, Keap1 (Kelch-like ECH-associated protein 1), a cysteine (Cys)-rich protein (27 Cys residues in human and 25 in mouse), normally binds Nrf2 (also called nuclear factor erythroid 2-like 2 or Nfe2l2), a master transcription factor for cellular antioxidant responses, and functions as an adaptor for a Cullin 3 (Cul3)-based E3 ubiquitin ligase complex to promote polyubiquitination and proteasomal degradation of Nrf2 31,32,33,34
