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When B12 levels are too low, the nerves can become damaged, leading to sensations like numbness, tingling, or a pins and needles feeling in the hands, feet, or legs
Strikingly, however, the proteomic analysis also revealed a drastic induction in heme oxygenase 1 (HMOX1) levels, which has an important function in protecting cells from oxidative damage 53 , in cells treated with the CRBN-based PROTAC 1a or VHL-based PROTAC 2c as well as in cells treated with CCW16 only ( Figure 2D, Supplementary Table I)
Just make sure to swab the stopper again before the second puncture and use proper sterile technique throughout
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