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Initially approved for type 2 diabetes (T2D) treatment, they were later found to influence appetite regulation (145, 146) by regulating activity in hedonic brain regions like the insula and orbitofrontal cortex changing food preference (147), therefore, leading to their approval for obesity and diabetes management (148150)
Role of GLP-1 in your body GLP-1 is a natural hormone your gut releases after a meal It signals the pancreas to release insulin and tells your brain youre satisfied By mimicking that action, medications can curb appetite and improve glucose levels Types of GLP-1 delivery Injectable options include weekly or daily shots (for example, semaglutide or liraglutide) Oral forms come as pills or drops, designed for people who prefer a needle-free route Each option delivers the same active ingredient, but absorption and dosing can differ Compare absorption and onset How quickly you feel benefits can hinge on how the medication enters your bloodstream
The results of HE staining showed that compared with the control group, the model group had swollen hepatocytes and vacuolar changes (mainly steatosis)
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