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Delayed gastric emptying Improved insulin secretion Enhanced insulin response Improved fat metabolism Synergistic amplification Increased thermogenesis Enhanced fat oxidation Elevated metabolic rate The progression from single to dual to triple agonist follows a clear pattern

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Notably, GLP-1R deletion in primary mouse astrocytes results in subtle mitochondrial dysfunction accompanied by a compensatory enhancement of glucose transporter-1-mediated aerobic glycolysis [22]

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