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This is related to an imbalance in reactive oxygen species (ROS) homeostasis, which is mainly regulated by mitochondrial function, thereby suggesting a link between oxidative impairment in mitochondrial function in response to chronic stress and mood instability ( 2+ ions, thereby creating a vicious cycle in which ROS enhance cytosolic Ca 2+ levels, and Ca 2+ enhances ROS production, which may worsen PTSD symptoms
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