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Strikingly, gene depletion of TBC1D15 or its scaffold AnxA6 upregulated endogenous Rab7-GTP levels to rescue cholesterol export in NPC1 mutants and enable transfer of cholesterol via the late endosomal cholesterol transporter StARD3 to the endoplasmic reticulum, followed by cholesterol esterification and cholesteryl ester storage in lipid droplets [12]
Author contributions ZH: Conceptualization, Methodology, Software, Validation, Visualization, Writing original draft, Writing review and editing
As a result the response function of a metabolite or a reaction velocity to changes in a parameter or input may be nonlinear and non-monotone
Neuroendocrinology
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