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SURMOUNT trials demonstrated that tirzepatide at maintenance doses produced 20-22% body weight reduction over 72 weeks, substantially exceeding results from GLP-1-only medications like semaglutide
Cellular thiamine status is coupled to function of mitochondrial 2-oxoglutarate dehydrogenase
Compounded tirzepatide prescriptions are limited to residents in the following states: AZ, CA, CO, CT, DE, FL, GA, HI, IA, ID, IL, KS, MA, MD, ME, MO, MS, MT, NC, ND, NE, NH, NJ, NM, NV, NY, OH, OK, OR, PA, RI, TN, TX, UT, VA, VT, WA, WI, WV, Washington D.C., WY
1 Although it was found to lower the risk of worsening heart failure in patients with heart failure with preserved ejection fraction and obesity in the SUMMIT trial (NCT04847557), tirzepatide has not been compared directly with semaglutide for this indication or at all for reducing the risk of MACE in patients with T2D
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