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Clinical features of slow transit constipation: Infrequent bowel movements (often 12 per week or less) Minimal urge to defecate Diffuse abdominal bloating and discomfort Confirmed by colonic transit studies (radio-opaque marker study or scintigraphy) Does not respond well to laxatives alone, often requires motility agents Documentation requirement: K59.01 should only be assigned when slow transit has been confirmed by objective transit studies (radio-opaque marker test, wireless capsule motility study, or colonic scintigraphy)
This product is not intended for use by children, pregnant or breastfeeding women
Analyses of changes after randomization used a landmark approach, beginning at week 20 and excluding events before that point, and were observational rather than causal
In the high-overdose patient (Patient D), the overall necrosis remained high, ranging from 30.4% to 39.3%
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