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10.1017/S0007114517001593 105
In addition, by reacting with oxidants such as superoxide anions, NO promotes cell injury and makes chondrocytes vulnerable to apoptosis induced by cytokines ( One study found that NO alone did not result in chondrocyte death but that NO triggered apoptosis when it reacted with O 2 - to produce chondrocytes (Del Carlo and Loeser, 2002)
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