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While these neurons were largely unaffected by LPS alone, semaglutide treatment strongly upregulated phosphodiesterase 10a ( Pde10a , Fig

Therefore, Ali Aminian, MD , and colleagues studied the renoprotective advantages of metabolic surgery in patients with obesity and CKD compared to patients who did not have surgery but continuously received GLP-1RA

If culprit medications remain clinically indicated, prescribers should use the lowest possible dose, a safer alternative with fewer adverse effects, or non-pharmacologic therapy, rather than initiating a cascade medication to address the ADE

Many patients notice improvement as their body adapts and reaches a stable maintenance dose