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Amide nitrogens are not acidic in isolation

CRP, an active regulator of host innate immunity, is a biomarker of chronic inflammatory conditions and severe COVID-19 disease, including lung and atherosclerotic disease progression

In this context, Zielman et al

Another principal function of the NADPH produced by ER-localized hexose-6-phosphate dehydrogenase is to provide the reducing energy to ER-localized reductases, specifically those involved in steroid hormone metabolism, with 11-hydroxysteroid dehydrogenase 1 (11-HSD1