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The connection is thought to be related to the weight loss itself, rather than a direct effect of the medication

Bacteriostatic Water is the recommended reconstitution solvent for the majority of lyophilised peptide and recombinant protein research compounds used in laboratory settings selected over unpreserved Sterile Water for Injection and standard buffer solutions when multi-use vial access, extended reconstituted peptide storage, or compatibility with benzyl alcohol-tolerant research compounds is required: Bacteriostatic Water is the standard reconstitution solvent for growth hormone secretagogue research peptides including GHRP-6, GHRP-2 Acetate, Ipamorelin, and Hexarelin and dissolving the lyophilised hexapeptide and pentapeptide powders to produce research-grade working solutions with maintained sterility across multiple withdrawal events

The possible mechanisms may involve effects on GLP-1 hormones, the authors of the trial hypothesize, "that are secreted from the gastrointestinal tract and affect appetite by regulating digestive processes and neural signaling in the central nervous system." Medicinal plants are also turning out to be fruitful areas of research