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These data support the potential of tirzepatide to reduce the risk of clinically meaningful kidney endpoints and encourage future trials in patients with type 2 diabetes and CKD. The open-label SURPASS 4 trial compared the safety and efficacy of three doses of tirzepatide with titrated insulin glargine among adults with type 2 diabetes at high risk for CV events

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BPC 157 has shown low toxicity in animal studies, but long-term human safety data remain limited