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ondansetron can cause constipation) For pain : Multimodal pain management including physiotherapy, appropriate analgesia, and psychological approaches For anxiety : Cognitive behavioural therapy (CBT), mindfulness-based interventions, or appropriate pharmacotherapy For sleep : Sleep hygiene education, cognitive behavioural therapy for insomnia (CBT-I) Patients should work collaboratively with their healthcare team to develop an individualised plan that supports both their weight management goals and overall health, recognising that successful treatment requires addressing all factors that may influence outcomes