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Extra weight increases mechanical stress on the knee, and "visceral adipose tissue secretes adipocytokines and other soluble mediators that increase pain." Felson added that the trial's findings are similar to those from a 2023 study that examined the effects of GLP-1 receptor agonists on adults who had both type 2 diabetes and knee osteoarthritis

The mechanism of action is based on the stimulation of the glucagon-like peptide-1 receptor, which enhances insulin secretion, slows gastric emptying, and supports overall metabolic regulation

Methods : This is an observational, cross-sectional study with data collected between 2021 and 2023

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